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Table 2 Summary of the estimated number and genetic diversities of T/F variants in SHIV SF162P3N ivg-infected macaques

From: The number and genetic relatedness of transmitted/founder virus impact clinical outcome in vaginal R5 SHIVSF162P3N infection

Clinical status

Animal

Sampling time point (wpi)

vRNA (copies/ml plasma) at time of sampling

No. of env sequences analyzed

No. of identified T/F viruses

Mean env diversity

Transient Viremic

DE37

2

2,939

44

1

0.0004

AH94

3

74,929

28

1

0.0006

Chronic Progressors

FR25

1

2,458

21

1

0.0005

CF18

1

1,413

19

1

0.0006

CG63

2

61,996,000*

20

1

0.0030

FV44

2

39,494

30

2

0.0030

FH84

2

36,073,000*

49

2

0.0032

GH62

2

3,902,206*

59#

2

0.0034

CG45

1

7,140

24

2

0.0126

GR56

3

1,186,674*

58#

2

0.0176

Rapid Progressors

GC70

2

67,857,860*

24

2

0.0052

DG17

1

10,844

29

3

0.0122

EL48

1

48,548

42

4

0.0130

 

EI77

1

17,119

38

2

0.0138

  1. *indicates time of peak viremia; # designates the two animals (GH62, GR56) where both SGA and conventional cloning was performed to generate the env sequences: 19 SGA and 40 cloning sequences for GH62 and 27 SGA and 31 cloning sequences for GR56 were analyzed. All the analyses were performed with a 660 bp env V3-V5 sequences.