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Table 2 Phosphorylated proteins differentially expressed when normalized to total proteins or actin levels

From: HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood–brain barrier interactions: modulatory role of CCR5

Phospho-protein/total protein

HIV vs. CONTROL

HIV + TAK vs. CONTROL

HIV vs. HIV + TAK

Name

Fold change

P-value

Fold change

P-value

Fold change

P-value

Merlin (Phospho-Ser518)

4.47

8.13E-12

1.39

8.97E-05

0.31

1.45E-10

VASP (Phospho-Ser157)

4.05

8.13E-12

1.29

0.00047

0.32

1.84E-11

ERK1-p44/42 MAP Kinase (Phospho-Tyr204)

2.38

4.31E-08

1.14

0.10

0.48

3.68E-09

Rac1/cdc42 (Phospho-Ser71)

2.24

1.28E-05

0.85

0.17

0.38

1.76E-07

Cortactin (Phospho-Tyr421)

1.20

8.13E-12

0.63

1.53E-10

0.31

1.84E-11

CaMK1-a (Phospho-Thr177)

1.93

5.75E-05

1.47

0.0092

0.76

0.00013

ERK1-p44/42 MAP Kinase (Phospho-Thr202)

1.74

6.72E-08

1.15

1.13E-05

0.66

3.71E-06

ERK3 (Phospho-Ser189)

1.68

7.74E-05

1.10

0.556

0.65

0.0035

MEK1(Phospho-Ser217)

1.47

0.00017

0.83

0.00034

0.57

4.63E-06

MKK6 (Phospho-Ser207)

0.49

8.13E-12

0.49

1.53E-10

1.01

0.96

FAK (Phospho-Tyr397)

0.44

8.13E-12

0.87

0.0552

1.97

8.0E-09

MKK7/MAP2K7 (Phospho-Ser271)

0.30

8.13E-12

0.81

0.0344

2.65

1.54E-09

Phospho-protein/actin

HIV vs. CONTROL

HIV + TAK vs. CONTROL

HIV vs. HIV + TAK

Name

Fold change

P-value

Fold change

P-value

Fold change

P-value

Merlin (Phospho-Ser518)

6.24

1.95E-11

1.15

0.079

0.184

1.16E-11

VASP (Phospho-Ser157)

4.38

1.95E-11

0.88

0.088

0.20

1.16E-11

Rac1/cdc42 (Phospho-Ser71)

3.56

3.67E-08

0.83

0.14

0.23

6.98E-10

ERK1-p44/42 MAP Kinase (Phospho-Tyr204)

3.26

9.42E-10

0.88

0.13

0.27

1.16E-11

Cortactin (Phospho-Tyr421)

2.93

1.96E-11

0.73

7.19E-08

0.25

1.16E-11

ERK1-p44/42 MAP Kinase (Phospho-Thr202)

2.55

1.2E-10

0.92

0.0028

0.34

3.18E-11

MEK1(Phospho-Ser217)

2.23

2.06E-08

0.74

2.35E-06

0.33

7.81E-10

CaMK1-a (Phospho-Thr177)

1.67

0.00038

1.08

0.91

0.64

3.19E-07

ERK3 (Phospho-Ser189)

1.61

0.00011

1.06

0.91

0.65

0.0026

MKK7/MAP2K7 (Phospho-Ser271)

0.73

1.51E-06

0.87

0.23

1.18

0.038

FAK (Phospho-Tyr397)

0.61

1.96E-11

0.64

2.82E-06

1.05

0.63

MKK6 (Phospho-Ser207)

0.60

1.96E-11

0.71

2.27E-06

1.17

0.00089

  1. P-values were adjusted using the Benjamini & Hochberg test.
  2. Unadjusted P values, P values adjusted for multiple comparisons using Tukey post-hoc test, and P values adjusted for false discovery rate using the Benjamini & Hochberg method were all significant. Table show P values adjusted using the Benjamini & Hochberg method.
  3. VASP: vasodilator-stimulated phosphoprotein; CaMK1: calcium/calmodulin-dependent protein kinase-1; ERK: extracellular signal-regulated kinases; MEK / MKK: mitogen-activated protein kinase kinase; FAK: focal adhesion kinase.
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Retrovirology

ISSN: 1742-4690

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