Skip to main content

Table 1 Differently expressed total proteins in HIV-infected-monocytes co-cultured with HBMEC

From: HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood–brain barrier interactions: modulatory role of CCR5

Protein

HIV vs. control fold change

P-value

HIV vs. TAK fold change

P-value

Location

Src

3.05

5.09E-10

0.67

3.34E-05

Cytoplasm

MKK3/MAP2K3

2.78

3.62E-09

0.41

1.16E-11

Cytoplasm

PKC alpha

2.56

7.34E-08

0.57

6.81E-06

Cytoplasm

p130Cas

2.51

2.06E-08

0.54

1.16E-11

Plasma membrane

MKK7/MAP2K7

2.41

5.47E-09

0.45

1.16E-11

Cytoplasm

CaMK2-beta/gamma/delta

2.40

1.61E-09

0.69

3.61E-04

Nucleus

Ezrin

2.22

4.15E-10

0.50

1.16E-11

Plasma membrane

PLC beta3

2.17

3.62E-09

0.48

1.09E-06

Cytoplasm

c-Raf

2.07

1.99E-11

0.57

1.29E-11

Cytoplasm

PLC-beta

2.04

7.50E-07

0.53

2.09E-10

Cytoplasm

WAVE1

2.02

3.19E-06

1.17

1.61E-03

Nucleus

LIMK1

1.99

1.99E-11

0.46

3.08E-11

Cytoplasm

Myosin regulatory light chain 2

1.99

5.47E-09

0.63

7.03E-11

Cytoplasm

  1. HBMEC: human brain microvascular endothelial cells; HIV: human immunodeficiency virus-1.
  2. Unadjusted P values, P values adjusted for multiple comparisons using Tukey post-hoc test, and P values adjusted for false discovery rate using the Benjamini & Hochberg method were all significant. Table show P values adjusted using the Benjamini & Hochberg method.
  3. Src: v-src sarcoma viral oncogene homolog; MKK3/MAP2K3: mitogen-activated protein kinase kinase3; PKC: protein kinase C; p130Cas: breast cancer anti-estrogen resistance 1; MKK7/MAP2K7: mitogen-activated protein kinase kinase 7; CAMK2: calcium/calmodulin-dependent protein kinase-2; PLC: phospholipase C; c-raf: v-raf-1 murine leukemia viral oncogene homolog 1; WAVE1: WAS protein family 1; LIMK1: LIM domain kinase 1.