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Figure 4 | Retrovirology

Figure 4

From: HIV-1 induces cytoskeletal alterations and Rac1 activation during monocyte-blood–brain barrier interactions: modulatory role of CCR5

Figure 4

Increased phosphorylation of Rac1(S71) in brain tissues of HIV-infected humans. (A-D) Western blot analyses show increased levels of pRac1 (S71) in brain tissues of HIV-positive individuals (HIV Pos, donors P8, P6, P5, P9, P2, and P4), compared to HIV-infected patients with encephalitis (HIVE, donors D7, D6, D8, and D10) and seronegative controls (HIV Neg, donors N5, N4, N7, N6, N11, and N12). (E) Increased levels of pRac1 (S71) and pERK1 (Thr202/Tyr204) in HIV-infected monocytes co-cultured with HBMEC, compared to non-infected monocytes co-cultured with HBMEC. TAK-779 and maraviroc diminished HIV-induced phosphorylation of Rac1 and ERK1/2.

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Retrovirology

ISSN: 1742-4690

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