Figure 1

CCR5 antagonists inhibits HIV-1 infection in MDM. MDM were infected with the macrophage tropic HIV-1_ADA, with or without maraviroc or TAK-779 (5 μM) in the media. Controls consisted of mock-infected cells. Culture supernatants were then collected every 2 or 3 days from day-5 to day-18 post-infection (p.i) and viral replication estimated by quantifying reverse transcriptase activities. From day-5 to day-18 p.i., both maraviroc (A-F) and TAK-779 (G-L) inhibited HIV-1 infection of MDM (***P < 0.001). This is representative data from 3 independent experiments with 3 different human donors, with each donor tested in triplicate.