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Table 2 Genotype frequencies and statistical significance for rs6622139 and rs1290413 in Chr.X- HERV-W env copy

From: HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV

rs6622139 (T → C)
Females
  Center of Spain South of Spain   
  MS Controls p-value OR (95% C.I) MS Controls p-value OR (95% C.I) p MH OR (95% C.I) MH
  n % n %   n % n %   
TT 413 70 245 66    353 65 338 66     
TC 167 28 108 29    170 32 148 29     
CC 13 2 18 5 0.02* 0.44 (0.20 -0.96) 16 3 27 5 0.06 0.55(0.28-1.08) 0.004** 0.50(0.31-0.81)
Males
  Center of Spain South of Spain   
  MS Controls p-value OR (95% C.I) MS Controls p-value OR (95% C.I) p MH OR (95% C.I) MH
  n % n %    n % n %     
T- 251 84 253 86 0.36 1.23 (0.77-1.99) 194 82 213 76 0.09 0.69(0.44-1.09) ------ ----------
C- 49 16 40 14 43 18 68 24
rs1290413 (G → A)
Females
  Center of Spain South of Spain   
  MS Controls p-value OR (95% C.I) MS Controls p-value OR (95% C.I) p MH OR (95% C.I) MH
  n % n %    n % n %     
GG 331 56 229 62    296 55 270 53     
GA 220 37 127 34    196 36 203 39     
AA 42 7 15 4 0.05* 1.81(0.96-3.47) 47 9 40 8 0.59 1.13(0.71-1.79) 0.10 1.34(0.94-1.91)
Males
  Center of Spain South of Spain   
  MS Controls p-value OR (95% C.I) MS Controls p-value OR (95% C.I) p MH OR (95% C.I) MH
  n % n %    n % n %     
G- 219 73 224 76 0.33 1.20(0.81-1.77) 173 73 208 74 0.79 1.05(0.70-1.59) 0.38 0.89(0.68-1.16)
A- 81 27 69 24 64 27 73 26
  1. *Statistically significant difference.