Figure 8

Model of NFκB mediated effects on RGH productivity in newly infected cells. Schematic representation of productive infection determination in RGH infected Jurkat cells. In cells with low NFκB activity, the majority of RGH infected cells exist in a non-productive state (eGFP- mCherry+, ‘red’) four days post infection, whereas cells with high NFκB activity have a greater propensity to exist in a productive state (eGFP+ mCherry+, ‘yellow’) and persist over time. TNFα stimulation of non-productively infected cells four days post infection only temporarily reactivates HIV-1, which reverts to its non-productive state days later.