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Table 1 HIV gene expression in HIV Tg mice

From: B cell lymphoma in hiv transgenic mice

  SPLEEN LYMPH NODE LYMPH NODE/SPLEEN
Mouse number T/B ratio HIV genes T/B ratio HIV genes HIV genes
   MS SS US   MS SS US MS SS US
M5 23/65 - - - 86/12 - - - - - -
M15 25/74 0.56 0.26 0.78 nd 2.56 1.4 1.48 4.57 5.38 1.90
M22 5/69 0.18 0.0 0.45 70/30 0.87 6.28 1.24 4.83 6.28 2.76
M21 3/60 0.20 0.48 0.68 30/70 0.7 0.91 1.11 3.50 1.90 1.63
M7 4/96 2.11 2.7 0.62 25/75 1.62 3.46 5.00 0.77 1.28 8.06
M16 5/83 0.66 1.53 0.87 12/78 0.87 2.67 1.20 1.32 1.75 1.38
M20 2/58 0.04 0.1 0.09 1/92 18.9 20 5.55 ˃100 >100 61.67
M13 1/83 1.36 1.37 0.43 5/95 1.9 2.44 7.81 1.40 1.78 18.16
M2 4/86 0.37 0.8 2.36 11/84 0.17 1.13 1.29 0.46 1.41 0.55
M11 2/90 1.64 5.12 0.96 1/92 0.77 1.78 1.14 0.47 0.35 1.19
  1. Viral RNA was quantified in HIV Tg mice at different stages of splenomegaly by semiquantitative real-time RT-PCR and was expressed as fold increase relative to the levels expressed in Tg 26 mice with no signs of disease. The lefts column indicates the numbers assigned to the mice. Both spleen (on the left) and lymph node (on the center) were analyzed for each mouse. The table shows T/B ratio and semiquantitative real-time RT-PCR of HIV MS (multiply spliced), SS (single spliced) and US (unspliced) RNAs. The ratio of the RNA levels in the lymph node versus that in the spleen of the same mouse is shown on the extreme right.