Figure 2
SHIV SF162P3N clone 8 and 11 replication in intrarectally challenge macaques. (A) Coreceptor usage in rhPBMC and the V3 loop sequence of SHIVSF162P3N clone 8 and 11, and (B) plasma viral RNA levels over time in the infected animals are shown. Coreceptor usage of the inoculating viruses was determined by blocking entry into rhPBMC with 1 μM CXCR4-specific (AMD3100) or CCR5-specific (TAK779) inhibitor. For V3 loop sequence, dashes stand for identity in sequences, and the net positive charge of this region is shown on the right. †in (B) indicates euthanasia with clinical symptoms of AIDS.