Table 3 Comparison of key parameters in Chinese RM and Indian RM following SIV infection
From: SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans
Innoculation route | SIV strains (Titer) | Rhesus macaque | Peak viral load (lg10) | Set point viral load (lg10)* | CD4 + T cells (%) | Antibody titer** | Survival time*** | Ref |
|---|---|---|---|---|---|---|---|---|
I.V. | mac239 | Chinese RM (n = 10) | 6.5–7.8 | ~2.8–6.7 | >50% (7 out of 10) | 10 out of 10 positive | NP | [20] |
(102 TCID50) | Indian RM (n = 4) | 7–8 | ~6–7 | <50% (2 out of 4) | 1 out of 4 | >17W (2/4) | ||
mac251 | Chinese RM (n = 8) | 5.8–7.5 | 2.5–5.8 | NP | NP | >154W (4/8) | [40] | |
(10 TCID50) | Indian RM (n = 6) | 6.9–7.8 | 4.5–7.3 | NP | NP | <52W | ||
mac251 | Chinese RM (n = 8) | 6.47–7.88 | 3.62–5.70 | 51% | ~103 | >43W (8/8) | [8] | |
(102 TCID50) | Indian RM (n = 15) | 6.64–8.30 | 4.37–7.30 | 49% | ~103 | >43W(10/15) | ||
IVAG | mac251 | Chinese RM (n = 10) | 7.2 | 5.0 | NP | 1.6 × 104–8 × 105 | NP | [22] |
(105 TCID50) | Indian RM (n = 16) | 7.7 | 6.3 | NP | 2 × 102–8 × 105 | NP |