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Table 3 Comparison of key parameters in Chinese RM and Indian RM following SIV infection

From: SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans

Innoculation route SIV strains (Titer) Rhesus macaque Peak viral load (lg10) Set point viral load (lg10)* CD4 + T cells (%) Antibody titer** Survival time*** Ref
I.V. mac239 Chinese RM (n = 10) 6.5–7.8 ~2.8–6.7 >50% (7 out of 10) 10 out of 10 positive NP [20]
(102 TCID50) Indian RM (n = 4) 7–8 ~6–7 <50% (2 out of 4) 1 out of 4 >17W (2/4)
mac251 Chinese RM (n = 8) 5.8–7.5 2.5–5.8 NP NP >154W (4/8) [40]
(10 TCID50) Indian RM (n = 6) 6.9–7.8 4.5–7.3 NP NP <52W
mac251 Chinese RM (n = 8) 6.47–7.88 3.62–5.70 51% ~103 >43W (8/8) [8]
(102 TCID50) Indian RM (n = 15) 6.64–8.30 4.37–7.30 49% ~103 >43W(10/15)
IVAG mac251 Chinese RM (n = 10) 7.2 5.0 NP 1.6 × 104–8 × 105 NP [22]
(105 TCID50) Indian RM (n = 16) 7.7 6.3 NP 2 × 102–8 × 105 NP
  1. *: Measured at day 35–77;
  2. **: Measured at wk15-16;
  3. ****W: Weeks.