Table 2 Clinical parameters in SHIV-infected Chinese RM
From: SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans
Animal no. | Age (Year)* | Gender | Inoculation** | SHIV strains | Dose AID50/TCID50*** | Peak viral load in plasma | Survival time (weeks)**** | Ref |
|---|---|---|---|---|---|---|---|---|
2 | 3.5–4.5 | mixed | I.R. | 89.6P | 40 AID50 | 8 × 105–7 × 106 | >24W | [41] |
10 | 6.1–7.1 | NP | I.V. | 89.6P | 103AID50 | 1 × 107 | >36W | [42] |
6 | 4–5 | NP | I.V. | 89.6P | 20 AID50 | ~2 × 105–3 × 106 | >40W (5/6) | [43] |
6 | 4–8 | NP | I.V. | 89.6P | 103 AID50 | NP | NP | [44] |
6 | NP | F | IVAG (13 times) | SF162P3 | 20, 30 TCID50 | 6.3 × 105–1.6 × 107 | >29W | [45] |
8 | 3–5 | F | I.V. | SF162P4 | 18 AID50 | 1.6 × 105–2.5 × 106 | >10W | [46] |
8 | 5–6 | F | I.V. | SF162P4 | 22 TCID50 | 1.6 × 105–3.2 × 106 | >10W | [47] |
12 | 3.5–7 | F | IVAG (6 times) | SF162P3 | 3 × 102 TCID50 | 1.1 × 106–3.5 × 106 | N/P | [48] |
4 | Adult | M | I.R. | SF162P3 | 10 TCID50 | ~106–107 | >32W | [49] |
10 | 5–15 | F | IVAG | SF162P3 | 3 × 102 TCID50 | 3.2 × 105–1 × 108 | ≥10W | [50] |
8 | NP | 7M/1F | I.R. (M) IVAG (F) | SF162p3 | 10 TCID50 | NP | NP | [51] |
4 | 8.09 (mean) | NP | I.R. | RT | 103 TCID50 | 1 × 104–2 × 106 | >20W | [52] |
2 | 104 TCID50 | 5 × 105–2 × 107 | >16W | |||||
5 | Adult | F | IVAG | RT | 103 TCID50 | 2 × 106–2 × 107 | >20W | [53] |
2 | 2 × 102 TCID50 | 1 × 106 (1/2) | >20W | |||||
16 | 4–12 | F | IVAG | RT | 103 TCID50 | 105–107 (9/16) | >16W | [54] |
30 | ~4 × 104–6 × 107 (22/30) |