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Table 2 Clinical parameters in SHIV-infected Chinese RM

From: SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans

Animal no. Age (Year)* Gender Inoculation** SHIV strains Dose AID50/TCID50*** Peak viral load in plasma Survival time (weeks)**** Ref
2 3.5–4.5 mixed I.R. 89.6P 40 AID50 8 × 105–7 × 106 >24W [41]
10 6.1–7.1 NP I.V. 89.6P 103AID50 1 × 107 >36W [42]
6 4–5 NP I.V. 89.6P 20 AID50 ~2 × 105–3 × 106 >40W (5/6) [43]
6 4–8 NP I.V. 89.6P 103 AID50 NP NP [44]
6 NP F IVAG (13 times) SF162P3 20, 30 TCID50 6.3 × 105–1.6 × 107 >29W [45]
8 3–5 F I.V. SF162P4 18 AID50 1.6 × 105–2.5 × 106 >10W [46]
8 5–6 F I.V. SF162P4 22 TCID50 1.6 × 105–3.2 × 106 >10W [47]
12 3.5–7 F IVAG (6 times) SF162P3 3 × 102 TCID50 1.1 × 106–3.5 × 106 N/P [48]
4 Adult M I.R. SF162P3 10 TCID50 ~106–107 >32W [49]
10 5–15 F IVAG SF162P3 3 × 102 TCID50 3.2 × 105–1 × 108 ≥10W [50]
8 NP 7M/1F I.R. (M) IVAG (F) SF162p3 10 TCID50 NP NP [51]
4 8.09 (mean) NP I.R. RT 103 TCID50 1 × 104–2 × 106 >20W [52]
2 104 TCID50 5 × 105–2 × 107 >16W
5 Adult F IVAG RT 103 TCID50 2 × 106–2 × 107 >20W [53]
2 2 × 102 TCID50 1 × 106 (1/2) >20W
16 4–12 F IVAG RT 103 TCID50 105–107 (9/16) >16W [54]
30 ~4 × 104–6 × 107 (22/30)
  1. *NP: The information is not provided in the paper;
  2. **I.R.: intrarectally; I.V.: intravenously; IVAG: intravaginally;
  3. ***TCID50: 50% tissue culture infective dose; AID50 : 50% animal infectious doses; Viral titer was quantified in different cells;
  4. ****W: Weeks; M: Months.