Table 1 Clinical parameters in SIV-infected Chinese RM
From: SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans
Animal no. | Age (Year)* | Gender | Inoculation** | SIV strains | Dose AID50/TCID50*** | Peak viral load | Survival time**** | Refs |
|---|---|---|---|---|---|---|---|---|
10 | 3–10 | 7F/3M | I.V. | mac239 | 102 TCID50 | 3.5 × 106–6.0 × 107 | >34W | [20] |
50 | 3–6 | 78M/72F | I.R. | mac239 | 5 × 105 TCID50 | 107 | >99W (25/50) | [9] |
50 | I.V. | mac239 | 2 × 102 TCID50 | 107 | >117W (25/50) | |||
8 | 5–11 | M | I.V. | mac239 | 5 × 103 TCID50 | 106–108 | >69W (4/8) | [27] |
4 | Adult | M | I.V. | mac239 | 5 × 103 TCID50 | 5 × 106–1 × 108 | NP | [28] |
3 | 3–6 | 2M/1F | I.V. | mac239 | 103 TCID50 | 3.2 × 106–3.2 × 107 | >25W | [29] |
3 | 3–8 | Mixed | I.R. | mac239 | 2.5 × 103 TCID50 | 106–107 | >44W | [30] |
9 | NP | NP | I.V. | mac239 | 102 TCID50 | ~106–108 | 104–354W | [31] |
7 | mac239 | 2 × 106 copies | 31–172W | |||||
1 | Adult | F | IVAG × 3 | mac239 | ~105 TCID50 | ~7.9 × 106 | >46W | [32] |
4 | NP | NP | I.V. | mac251 | 5 × 102 TCID50 | 106–2 × 108 | >18M | [33] |
8 | mac239 | NP | >36M | |||||
24 | 5 | M | I.R. | mac239 | 103 TCID50 | 105–5 × 107 | >24W | [34] |
2 | 5–6 | F | IVAG | mac239 | 105 TCID50 | 2.5 × 106–3.2 × 106 | >25W | [35] |
50 | 3–6 | NP | I.V. | mac251 | 2 × 102 TCID50 | 5 × 106 | >118W (27/50) | [9] |
14 | 4–5 | F | I.V. | mac251 | 105 TCID50 | 1.1 × 105–1.2 × 108 | NP | [22] |
10 | 4–6 | F | I.V. | mac251 | 50 TCID50 | 2.4 × 104–1.4 × 106 | 51-72W | [36] |
6 | NP | NP | I.V. | mac251 | 10 AID50 | 7.0 × 105–3.2 × 107 | NP | [37] |
10 | 7.5–9.5 | NP | I.V. | mac251 | 10 AID50 | 2.6 × 105–3.6 × 107 | NP | [12] |
12 | NP | NP | I.V. | mac251 | 10 AID50 | 105–108 | 5–108W (killed) | [38] |
4 | 2–4 | mixed | I.V. | mac251 | 5 AID100 | 2.7 × 107–7.6 × 107 | >42W | [39] |
8 | NP | NP | I.V | mac251 | 10 AID50 | 6.7 × 105–3.2 × 107 | >154W (4/8) | [40] |