Skip to main content

Table 1 Clinical parameters in SIV-infected Chinese RM

From: SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans

Animal no. Age (Year)* Gender Inoculation** SIV strains Dose AID50/TCID50*** Peak viral load Survival time**** Refs
10 3–10 7F/3M I.V. mac239 102 TCID50 3.5 × 106–6.0 × 107 >34W [20]
50 3–6 78M/72F I.R. mac239 5 × 105 TCID50 107 >99W (25/50) [9]
50 I.V. mac239 2 × 102 TCID50 107 >117W (25/50)
8 5–11 M I.V. mac239 5 × 103 TCID50 106–108 >69W (4/8) [27]
4 Adult M I.V. mac239 5 × 103 TCID50 5 × 106–1 × 108 NP [28]
3 3–6 2M/1F I.V. mac239 103 TCID50 3.2 × 106–3.2 × 107 >25W [29]
3 3–8 Mixed I.R. mac239 2.5 × 103 TCID50 106–107 >44W [30]
9 NP NP I.V. mac239 102 TCID50 ~106–108 104–354W [31]
7 mac239 2 × 106 copies 31–172W
1 Adult F IVAG × 3 mac239 ~105 TCID50 ~7.9 × 106 >46W [32]
4 NP NP I.V. mac251 5 × 102 TCID50 106–2 × 108 >18M [33]
8 mac239 NP >36M
24 5 M I.R. mac239 103 TCID50 105–5 × 107 >24W [34]
2 5–6 F IVAG mac239 105 TCID50 2.5 × 106–3.2 × 106 >25W [35]
50 3–6 NP I.V. mac251 2 × 102 TCID50 5 × 106 >118W (27/50) [9]
14 4–5 F I.V. mac251 105 TCID50 1.1 × 105–1.2 × 108 NP [22]
10 4–6 F I.V. mac251 50 TCID50 2.4 × 104–1.4 × 106 51-72W [36]
6 NP NP I.V. mac251 10 AID50 7.0 × 105–3.2 × 107 NP [37]
10 7.5–9.5 NP I.V. mac251 10 AID50 2.6 × 105–3.6 × 107 NP [12]
12 NP NP I.V. mac251 10 AID50 105–108 5–108W (killed) [38]
4 2–4 mixed I.V. mac251 5 AID100 2.7 × 107–7.6 × 107 >42W [39]
8 NP NP I.V mac251 10 AID50 6.7 × 105–3.2 × 107 >154W (4/8) [40]
  1. *NP: The information is not provided in the paper;
  2. **I.R.: intrarectally; I.V.: intravenously; IVAG: intravaginally;
  3. ***TCID50: 50% tissue culture infective dose; AID50 : 50% animal infectious doses; Viral titer was quantified in different cells;
  4. ****W: Weeks; M: Months.