Figure 4From: A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus releaseEffect of variants on the susceptibility of tetherin to antagonism by Vpu. Virus release from 293T cells following transfection with the wild-type proviral HIV-1 NL4-3 construct and varying amounts of tetherin expression plasmids. Results obtained with the vpu-deficient proviral construct are shown in the upper panel for comparison. Infectious virus release was determined as described in the legend of Figure 3. Shown are average values ± SD derived from two independent experiments, each performed in triplicate.Back to article page