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Figure 2 | Retrovirology

Figure 2

From: A rare missense variant abrogates the signaling activity of tetherin/BST-2 without affecting its effect on virus release

Figure 2

Effect of variants on cell surface expression and internalization of tetherin. (A) FACS analysis of 293T cells transfected with vectors expressing the indicated tetherin variants. Shown are results obtained with the antibody from Chugai Pharmaceuticals (B) Cell surface expression levels of all tetherin variants. Shown are average values ± SD (n = 2) of the mean fluorescence intensities (MFIs) measured for the indicated tetherin variants relative to those obtained for the wild-type tetherin protein (100%). (C) Internalization rate of surface tetherin in 293T cells transfected with the indicated tetherin variants. Shown are average values ± SEM (n = 2).

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Retrovirology

ISSN: 1742-4690

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