Figure 1
From: HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358
HIV-1 CAN:NUP358Cyp complex. (a) Sequence alignment of NUP358Cyp with CypA (conserved regions are shaded and in bold). (b) Structural alignment of NUP358Cyp (yellow) from our structure with CypA (gray) from the HIV-1 CAN:CypA structure (pdb 1AK4 [23]. (c) HIV-1 CAN (green) bound to CypA (molecular surface; gray) (pdb 1AK4 [23]). (d) HIV-1 CAN (green) bound to NUP358Cyp (molecular surface; yellow). (e) Detailed view of interactions between the CypA-binding loop of HIV-1 CAN (green ball-and-stick) and CypA (gray). (f) Detailed view of interactions between the CypA-binding loop of HIV-1 CAN (green ball-and-stick) and NUP358Cyp (yellow). NUP358Cyp residues are numbered according to the equivalent CypA numbering. (g-h) Structure of CypA:Cs complex (2RMA [24]) (g) or model where NUP358Cyp has been substituted for CypA (h). Cs is in green.