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Figure 2 | Retrovirology

Figure 2

From: Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture

Figure 2

Replication kinetic assay of HIV-1 recoded protease variants. (A) MT-4 cells, (B) PBMCs. Production of the HIV-1 antigen p24 in culture supernatants was determined on days 0–5 (MT-4 cells) and on days 2–7 (PBMCs). For each virus, the slope of the plot provides an estimate of the viral replication capacity. The slope of the p24 antigen production of each virus after infection of MT-4 cells and PBMCs is shown by the bars. Comparisons between wild-type (HXB2) and mutant recoded viruses are shown. The significance of the difference between slopes was calculated with GraphPrism v. 4 software (unpaired t-test). Values represent the mean ± standard deviation (SD) from at least three independent experiments.

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Retrovirology

ISSN: 1742-4690

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