Figure 5

Structure of lentiviral capsids bound to human CypA reveals distinctive groups of interactions amongst the different circulating SIV capsids. (A) HIV-1 CA crystal structure (gold ribbon) bound to human CypA (grey ribbon) as compiled in the databanks (PDB: 1M9C; http://www.resbiorg/pdb/explore.do?structureId=1m9c). The Glycine and proline residues at position 89 and 90, respectively, are indicated in red and with an arrow on HIV-1 CA and at the equivalent positions on the different circulating SIV. HIV-1 CA-CypA crystal structure is used as template to predict the CA structure of different circulating SIV (see Figure 1 legend). (B) CA of SIVmnd-1, shown as a blue ribbon, is superimposed on HIV CA. (C) Superimposition of the three CA that belong to the SIVgsn lineage, SIVgsn, in blue; SIVmon, in pink; and SIVmus-1, in green. (D) CA of SIVcol, in pink, superimposed with HIV-1 CA.