Figure 4

Comparison of post-therapy viral DNA reduction in animals treated with H-iART/auranofin (AU) and H-iART/auranofin/BSO. Delta (Δ) viral DNA is shown as the Log ₁₀ difference between the medians of pre-therapy and post-therapy viral DNA levels (limit of detection of the assay: 2 DNA copies/5*10⁵ cells). Means and SEM are displayed in the figure. Pre-therapy values represent those at start of the H-iART therapy. To avoid biases (i.e. false negative values), post-therapy values were calculated from all available measurements (time window: 189 ± 55 days) following the novel acute infection phase at viral rebound. Data were analyzed by two tailed Student t-test. Macaques were matched by similarity of treatments and pre-therapy viral load set point.