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Figure 6 | Retrovirology

Figure 6

From: Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay

Figure 6

Viral RNA staining is altered by mutations that affect capsid stability. TZM-bl cells were infected with (A) EU-labeled WT, E45A, K203A, 5Mut, and E45A/R132T HIV-1; or (B) EU-labeled WT and 5Mut HIV-1 in the presence and absence of 10 μM PF74. 0.6 - 4.4 vRNA puncta were detected per cell. Data represent the mean ± SEM of at least 4 fields and the first time point was normalized to 1. Asterisks denote statistically significant p values (p < 0.05) between WT and each mutant or with or without PF74 treatment at each time point. The graphs are representative of 2 independent experiments.

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