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Table 1 Surface accessibility (SA) and phylogenetic conservation of IN residues implicated in INI1 binding

From: INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo

  Surface accessibilitya % identity among lentivirusesb
HIV-1 IN residue IN dimer IN tetramer HIV-1 and SIVcpz Non-HIV-1/SIVcpzprimate lentiviruses
  A B A B C D   
K71 118 79 90 94 99 99 98 85
K111 65 81 122 115 138 113 93 32
Q137 71 102 59 56 47 56 91 24
S147 71 N/A N/A N/A N/A N/A 100 100
D202 71 61 68 50 55 50 100 14
  1. aDetermined using PISA program based on IN crystal structures of dimer and tetramer (PDB#s 1ex4 and 1k6y, respectively).
  2. bDetermined using HIV Sequence Compendium (2010).