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Figure 5 | Retrovirology

Figure 5

From: INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo

Figure 5

Ultrastructural analysis of producer cells expressing IID-IN mutants: A. 293 T cells transfected with pNL4-3 harboring WT or IID-IN mutants were fixed 6 hours post-media change in buffer containing 2.5% glutaraldehyde and post-fixed with 1% osmium tetroxide. Cut sections were imaged on a JEOL 1200EX and images were captured at ×20,000 magnification. Insets are zoom-in images of representative virions. B. Quantitation of virion morphologies from various IID-IN mutants. Morphology of 50-70 virions was analyzed for each category of virus, mutant or wild-type.

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Retrovirology

ISSN: 1742-4690

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