Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

Retrovirology

Table 2 Enhancement of hypersusceptibility to EFdA-TP under ATP-based excision conditions

Enzyme	IC₅₀(nM) of EFdA-TP ± SD (Fold change)		Hypersusceptibility enhancement in the presence of ATP
	Without ATP	With 3.5 mM ATP
WT RT	186 ± 40^a (1)^b	318 ± 99^a (1)^b	1^c
K65R RT	125 ± 28^a (0.7)^b	131 ± 28^a (0.4)^b	1.8^c

^aThe data show “mean value ± standard deviation” obtained from the results of at least four independent experiments (P < 0.011).
^bThe relative increase in IC₅₀ value in K65R RT compared with WT RT without, or with ATP is given in parentheses.
^cThe effect of ATP-based excision on hypersusceptibility is calculated by the relative change in IC₅₀ for K65R compared to WT RT without ATP/the relative change in IC₅₀ for K65R compared to WT RT with ATP.

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