Hypersusceptibility enhancement in the presence of ATP
With 3.5 mM ATP
186 ± 40a (1)b
318 ± 99a (1)b
125 ± 28a (0.7)b
131 ± 28a (0.4)b
aThe data show “mean value ± standard deviation” obtained from the results of at least four independent experiments (P < 0.011).
bThe relative increase in IC50 value in K65R RT compared with WT RT without, or with ATP is given in parentheses.
cThe effect of ATP-based excision on hypersusceptibility is calculated by the relative change in IC50 for K65R compared to WT RT without ATP/the relative change in IC50 for K65R compared to WT RT with ATP.