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Table 2 Enhancement of hypersusceptibility to EFdA-TP under ATP-based excision conditions

From: Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA

Enzyme IC50(nM) of EFdA-TP ± SD (Fold change) Hypersusceptibility enhancement in the presence of ATP
  Without ATP With 3.5 mM ATP  
WT RT 186 ± 40a (1)b 318 ± 99a (1)b 1c
K65R RT 125 ± 28a (0.7)b 131 ± 28a (0.4)b 1.8c
  1. aThe data show “mean value ± standard deviation” obtained from the results of at least four independent experiments (P < 0.011).
  2. bThe relative increase in IC50 value in K65R RT compared with WT RT without, or with ATP is given in parentheses.
  3. cThe effect of ATP-based excision on hypersusceptibility is calculated by the relative change in IC50 for K65R compared to WT RT without ATP/the relative change in IC50 for K65R compared to WT RT with ATP.