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Figure 6 | Retrovirology

Figure 6

From: Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence

Figure 6

Cognitive performance of SCID mice exposed to HIV-1 and controls evaluated on the WRAM during the asymptotic testing phase (data represent mean ±SE ). A. Analysis of working memory errors collapsed across days 11 and 12 and trials revealed Southern African HIV-1C1084i and HIV-1BADA exposed mice made significantly more RRM errors than the Control (ps < 0.018) and HIV − 1CIndieC1-exposed mice B. RRM errors committed on Day 13 post-45m delay trials 3 and 4, the Southern African HIV-1C1084i and HIV-1BADA but not HIV − 1CIndieC1 exposed mice committing more RRM errors as compared to the Control group. Group rankings for RRM errors committed on the delay followed a linear trend, with the Control group committing no errors, and the HIV-1BADA group committing the most. C. Analysis of Working Memory Correct errors committed on trial 4, when working memory load was the highest HIV-1CIndieC1 exposed mice did not differ from the Control group, but the Southern African HIV-1C1084i and HIV-1BADA exposed mice committed more errors. * p < 0.05; ^ p < 0.05 linear trend. D.Evaluation of Reference Memory Repeat errors committed on trial 4, the HIV-1C1084i and HIV-1BADA (i.e., mice exposed to HIV-1 with an intact dicysteine motif) committed more working memory errors when compared to the Control and HIV-1IndieC1 (clade C HIV-1 with C31S substitution in Tat) groups.

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