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Table 1 Stage-specific antiviral activity of LEDGINs

From: LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

 

EC50(μM)

 

Multiple round a

Early stage b

Late stage b

CX05045

1.14±0.32

4.45±2.34

1.46±0.01

Raltegravir

0.006±0023

0.0031±0.0013

> 3

Ritonavir

0.05±0.0027

>3

0.04±0.006

  1. a Effective concentration required to reduce HIV-1 induced cytopathic effect by 50% in MT-4 cells as determined by an MTT/MT-4 assay. b Effective concentration required to reduce Tat-driven beta-galactosidase expression by 50% in HeLaP4 cells at 24 hpi. Mean values ± standard deviations from at least two independent experiments are shown.
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Retrovirology

ISSN: 1742-4690

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