Skip to main content
Figure 3 | Retrovirology

Figure 3

From: The frantic play of the concealed HIV envelope cytoplasmic tail

Figure 3

Schematic representation of the interacting partners of the gp41-CT in the cell. The Env precursor gp160 is synthesized in the rough endothelial reticulum (RER), where it is glycosylated and oligomerizes into trimers. Furin cleavage in the Golgi apparatus enables the formation of the gp120-gp41 structure. Once it reaches the plasma membrane (PM), Env is subject to endocytosis, via the Y712SPL and L855L856 motifs interacting with AP-1 and AP-2. Cycling through the trans Golgi network and between endosomes is ensured through interactions with TIP47, via the Y802W803 diaromatic domain, and with AP-1 via Y712SPL. Env is targeted to the PM through Y712SPL interaction with AP-1 and AP-3. The p55Gag precursor is synthesized in the cytoplasm and accumulates at the PM in lipid raft-rich domains. Interaction of the gp41-CT (through LLP-2) with the Matrix protein (MA) ensures Env incorporation into the budding virion. gp41-CT interacts with Nef through L855L856. NF-κB activation through phosphorylation of IκB is mediated by interaction of the Y768 with TAK-1. Interference with luman-mediated inhibition of transcription is mediated by LLP-2. Abbreviations: RER: rough endoplasmic reticulum; TGN: trans Golgi network; CaM: calmodulin; LLP: lentiviral lytic peptide; TAK: TFG-β-activating factor; AP: adaptor protein: TIP47: Tail-interacting protein 47 kDa; Ub: ubiquitin ; Phb: Prohibitin.

Back to article page