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Figure 5 | Retrovirology

Figure 5

From: Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells

Figure 5

Suppression of NF-κB activity by IFN-α in HTLV-1-infected cells. A. ILT-Hod and ILT-#29 cells that were infected with lentiviral vectors containing reporter gene for the NF-κB responsive element and the TK-promoter several weeks before, were treated with or without IFN-α (3000 IU/ml) and/or AZT (10 μM) for 4 days as indicated. Luciferase activities were measured, and relative NF-κB activities normalized to TK-promoter activities were indicated as means and SD of duplicate samples. *p < 0.05. B. The levels of mRNA of VEGF, a NF-κB-regulated gene, in ILT-Hod and ILT-#29 cells 3 days after incubation with (closed bar) or without (open bar) IFN-α (3000 IU/ml) were quantified by RT-PCR and standardized to GAPDH mRNA. The relative values are indicated as means and SD of duplicate samples. *p < 0.05.

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