Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

Table 1 The expression of pro-inflammatory cytokines in peripheral blood mononuclear cells of HTLV-1 infected individuals

Case	Age	Sex	PVL^a	%IFN- $γ$ ⁺in	%IFN- $γ$ ⁺in	%IFN- $γ$ ⁺in	%IFN- $γ$ ⁺in	% TNF-α⁺in	% TNF-α⁺in	% TNF-α⁺in	% TNF-α⁺in
				CD4⁺OX40^+b	CD4⁺OX40^-	CD4⁺Tax^+c	CD4⁺Tax^-	CD4⁺OX40⁺	CD4⁺OX40^-	CD4⁺Tax⁺	CD4⁺Tax^-
HAM/TSP7	68	F	1200	56.3	8.9	74.1	12.4	66.9	26.1	70.8	25.3
HAM/TSP8	68	F	1118	77.2	5.0	91.5	4.7	84.1	10.0	87.6	10.7
HAM/TSP9	71	F	1424	64.8	4.7	80.1	5.3	70.4	18.8	80.5	16.6
mean±SE	69.0±1.0		1247±65	66.1±4.3	6.2±1.0	81.9±3.6	7.5±1.7	73.8±3.7	18.3±3.3	79.6±3.4	17.5±3.0
AC4	74	F	435	61.9	13.8	61.8	13.6	30.8	11.5	25.0	11.1
AC5	76	M	139	55.3	24.9	43.0	27.8	38.3	22.1	47.9	14.3
AC6	71	F	250	47.3	15.0	62.1	34.6	15.8	10.5	34.8	21.9
mean±SE	73.7±1.5		275±61	54.8±3.0	17.9±2.5	55.6±4.5	25.3±4.4	28.3±4.7	14.7±2.6	35.9±4.7	15.8±2.3

HAM/TSP: HTLV-1 associated myelopathy/tropical spastic paraparesis. AC: asymptomatic carrier. PVL: Proviral load.
^a PVL: HTLV-1 tax copy number per 10⁴ peripheral blood mononuclear cells (PBMCs).
^{b “}%IFN-γ⁺ in CD4⁺OX40^+” means the frequency of IFN-γ⁺ cells in the CD4⁺OX40⁺ cell gate.
^{c “}%IFN-γ⁺ in CD4⁺Tax^+” means the frequency of IFN-γ ⁺ cells in the CD4⁺Tax⁺ cell gate.

ISSN: 1742-4690