Figure 5
From: High level of susceptibility to human TRIM5α conferred by HIV-2 capsid sequences
Impact of the CA residues 119, 159, and 178 on hTRIM5α susceptibility. (A) hTRIM5α susceptibility of HIV-1 chimeric viruses that are stratified by the presence of proline (P) or no proline residue (N) at each of the CA positions 119, 159 and 178. For example, PPP = proline residues at positions 119, 159 and 178, NNN = no proline at the three positions. (B) hTRIM5α susceptibility values of HIV-1 chimeric virus carrying GL-AN capsid sequence (CA-GL-AN) and of its corresponding mutants CA-GL-AN P119A, CA-GL-AN P159S, CA-GL-AN P178A, CA-GL-AN P159S-P178A, and CA-GL-AN P119A- P159S-P178A were compared. The results shown are the mean ± SEM for 3 independent experiments.