Log of the ratio between the median ER measured WH and BH. A) In patient PIC1362 and B) for all the datasets. In panel A, the boxes are the 95% confidence interval. The thick line indicates the C2V5 segment (studied by earlier studies) and the thick dashed line indicates the whole ENV1 segment. In panel B, the colour code is the same as in Figure 3. In the env gene (the shaded yellow area) the ratio between WH ER and BH ER is significantly higher.