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Figure 9 | Retrovirology

Figure 9

From: A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Figure 9

MVC-resistant Envs remain sensitive to inhibition by the CCR5 ECL2-directed antibody 2D7. NP2-CD4/CCR5 cells were preincubated with increasing concentrations of 2D7 prior to infection with luciferase reporter viruses pseudotyped with Envs from subject 17 (A) or 24 (B). Infections with 17-Res and 24-Res Envs were also performed in the presence of 10 µM MVC. The data are expressed as percentage inhibition, where inhibition in untreated cells was set to zero. The data shown are the mean and SEM of three independent experiments. Inhibition curves were constructed using Prism, version 4.0c (GraphPad).

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