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Figure 7 | Retrovirology

Figure 7

From: A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Figure 7

Inhibition of 24-Res Env by sCCR5 1-22 is more pronounced in cells expressing lower levels of CCR5. JC53 cells, which express substantially lower levels of CCR5 than NP2-CD4/CCR5 cells [58], were infected with luciferase reporter viruses pseudotyped with 24-Res Env in the presence of 10 µM MVC and increasing concentrations of either scrambled peptide or sulfated sCCR51-22 peptide. The data are expressed as the percentage entry of that obtained in cells incubated with no inhibitor. The data points shown are the mean and SEM of triplicates, and are representative of three independent experiments.

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