Figure 3

Computational models of electrostatic surface potential on multiple forms of gp120. (A) Ribbon and space-filling models of gp120 core construct (PDB code 2NY7). (B) Electrostatic potential over a range of pH/pλ conditions of b12-bound core and CD4 and 17b bound core gp120 constructs, and the difference between structures. (C) Space-filling surface maps indicate the local changes surface potential of 6 gp120 constructs across pH, ranging from fully protonated (blue) to fully deprotonated (red).