Figure 1
From: Molecular signatures of T-cell inhibition in HIV-1 infection
Infection with HIV facilitates the upregulation of inhibitory molecules in T cells. HIV-1 modulates host DCs to increase expression of numerous inhibitory molecules on expanded T cells. The expanded T cells are suppressor T cells [4] that act on other T cells present in the near vicinity in a contact-dependent manner [4], transforming them into suppressor cells and so contributing to eventual T-cell inhibition [3–5].