Figure 1

Phylogenetic comparison of virus env sequences from the plasma of postnatally-infected infants (red squares) and paired mother’s milk (blue circles). The infant of maternal subject 1209 (A) was first HIV DNA positive at 6 months of age, but a plasma sample was not available for virus sequencing until 12 months of age, thus infant virus evolution away from the transmitted maternal variant had occurred. The infant of maternal subject 4403 (B) was first HIV DNA positive at 3 months of age and infant plasma virus sequencing was performed from a sample collected at the same timepoint. The consensus of the infant plasma env sequences was confirmed to be identical to the maternal breast milk variant 4403 bmC5 by highlight plot (C). The postnatally-T/F variant from subject 4403 and the maternal milk env variant most closely related to the transmitted variant from subject 1209 are indicated with a red star.