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Figure 4 | Retrovirology

Figure 4

From: The V86M mutation in HIV-1 capsid confers resistance to TRIM5α by abrogation of cyclophilin A-dependent restriction and enhancement of viral nuclear import

Figure 4

Direct correlation between the effect of mutation V86M and the effect of CsA treatment. The increase in HIV-1 infectivity in TE671 cells expressing the indicated TRIM5αhu in presence of 2 μM CsA was plotted against the increase in infectivity resulting from the V86M mutation. All values are –fold increases relative to the untreated WT control virus. Data were gathered at a multiplicity of infection yielding close to 1% infected cells for the untreated WT HIV-1 in the cell lines expressing each the various TRIM5α. The correlation is significant, as shown by the R2 obtained and the Spearman’s P-value. The linear regression equation is shown.

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Retrovirology

ISSN: 1742-4690

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