Table 2 Comparison of sensitivities and specificities of alternative algorithms and tools for predicting C-HIV coreceptor usage
From: CoRSeqV3-C: a novel HIV-1 subtype C specific V3 sequence based coreceptor usage prediction algorithm
Coreceptor specificity prediction technique | One C-HIV V3 sequence per subject | All C-HIV V3 sequences | ||
|---|---|---|---|---|
| Â | (Data set 1; 69 CXCR4-using and 473 R5) | (Data set 2; 143 CXCR4-using and 1213 R5) | ||
| Â | Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) |
CoRSeqV3-C | 94.20 | 91.12 | 90.85 | 99.98 |
Geno2pheno[coreceptor] | 88.41 | 94.71 | 87.32 | 99.96 |
WebPSSMSINSI-C | 88.41 | 90.7 | 88.02 | 99.86 |
WebPSSMX4R5-B | 78.26 | 95.76 | 69.72 | 99.94 |
WebPSSMSINSI-B | 59.42 | 99.36 | 57.04 | 99.98 |
11/25 | 46.38 | 98.94 | 47.87 | 99.99 |
11/24/25 | 56.52 | 97.25 | 52.12 | 99.99 |
11/25/V3 charge | 79.71 | 88.16 | 77.47 | 99.96 |
Lin et al. rule | 84.06 | 96.83 | 79.58 | 99.96 |