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Figure 4 | Retrovirology

Figure 4

From: Evidence for IFNα-induced, SAMHD1-independent inhibitors of early HIV-1 infection

Figure 4

SAMHD1 is induced by IFNα in U87-MG cells, but Vpx triggered degradation does not rescue IFNα-mediated HIV-1 suppression. A. U87-MG cells were treated for 24 h with IFNα, or not, and incubated with no VLPs, Vpx-VLPs, or control VLPs (Ctrl-VLPs) and then infected with increasing amounts of GFP reporter virus (MOI 0.008 to 1), and GFP expression monitored as before. The mean values from 3 independent experiments are shown. B. Western blot analysis of a parallel samples from A. Protein levels of SAMHD1 were determined and tubulin served as a loading control.

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