Figure 4
From: Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure
Effect of the H51Y and R263K mutations on integrase structure. Effect of residues at position 51 and 263 on local side-chain electrostatic interactions and side-chain mobility of: A. INwt (turquoise backbone); B. INH51Y (purple backbone); C. INR263K (salmon backbone) and D. INH51Y/R263K (Dark green backbone). Highlighted residues are shown as sticks within partly transparent space-filling structures coloured according to standard atomic colouration. Suspected hydrogen-bonding (<3.5Å) and electrostatic interactions (<4.5 Å) are represented by dotted black lines.