Figure 1
From: Viral fitness cost prevents HIV-1 from evading dolutegravir drug pressure
Strand-transfer activities of purified recombinant integrase proteins. (A) Recombinant integrase proteins INWT, INH51Y, INR263K, and INH51Y/R263K were purified (lanes 2 to 5) and (B) used to measure strand-transfer activity in relative fluorescent units (RFU/h) in the presence of 18 nM target DNA and various concentrations of purified recombinant protein. (B) Strand transfer activity (in RFU/h) in the presence of 450 nM purified recombinant protein and the indicated concentration of target DNA. Lines are fits; error bars indicate ± s.e.m.