HIV-1 envelope replication and α4β7 utilization among newly infected subjects and their corresponding heterosexual partners

Table 1 Demographics, viral and coreceptor characteristics

Couple	Type¹	Int. days²	Partner interval³	Recipient CCR5⁴	Recipient CXCR4⁵	Recipient tropism⁶	Transmitter CCR5	Transmitter CXCR4	Transmitter tropism
HF	FTM	17	3	7.24	<0.1	R5	8.27	<0.1	R5
888	MTF	74	19	10.39	<0.1	R5	11.91	<0.1	R5
890	MTF	138	12	3.79	<0.1	R5	2.27	<0.1	R5
394	MTF	93	2	7.79	<0.1	R5	10.85	<0.1	R5
927	MTF	324	46	12.55	<0.1	R5	13.37	<0.1	R5
2769	MTF	149	46	5.69	<0.1	R5	5.34	0.65	R5/X4
2810	MTF	161	23	5.49	<0.1	R5	6.12	<0.1	R5
SR-5	MTF	17	0	12.62	<0.1	R5	9.72	<0.1	R5
SR-20	MTF	91	34	6.70	<0.1	R5	7.24	<0.1	R5

¹FTM: female to male; MTF: male to female.
²Interval in days from the estimated date of acquisition to the day of sample collection for the newly infected partner. For seronegative individuals, interval was estimated as a maximum of 17 days.
³Interval in days between sampling of the two partners within a couple.
⁴P24 (ug/ml) from U87/CD4/CCR5 cells at day 4 post-infection.
⁵ P24 (ug/ml) from U87/CD4/CCR5 cells at day 4 post-infection.
⁶Tropism as determined on U87/CD4+/CCR5 and U87/CD4+/CXCR4 cells.