Table 2 Selected genes downregulated in Th1Th17 vs. Th1
Gene symbol | Fold change Th1Th17/Th1 | p-value | Gene title |
|---|---|---|---|
XCL1 | −7,53 | 0,001 | Chemokine (C motif) ligand 1 |
IL5 | −3,35 | 0,010 | Interleukin 5 (colony-stimulating factor, eosinophil) |
KLRK1 | −2,66 | 0,003 | Killer cell lectin-like receptor subfamily K, member 1 |
LAIR2 | −2,57 | 0,004 | Leukocyte-associated immunoglobulin-like receptor 2 |
IL4 | −2,47 | 0,013 | Interleukin 4 |
TIGIT | −2,36 | 0,001 | T cell immunoreceptor with Ig and ITIM domains |
CDH1 | −2,35 | 0,000 | Cadherin 1, type 1, E-cadherin (epithelial) |
IL17RB | −2,33 | 0,005 | Interleukin 17 receptor B |
CXCL10 | −2,31 | 0,046 | Chemokine (C-X-C motif) ligand 10 |
FCRL3 | −2,30 | 0,048 | Fc receptor-like 3 |
IL-17RB | −2,19 | 0,003 | Interleukin 17 receptor B |
SLAMF7 | −2,08 | 0,027 | SLAM family member 7 |
PTK2 | −2,01 | 0,000 | PTK2 protein tyrosine kinase 2 |
CXCR5 | −2,00 | 0,013 | Chemokine (C-X-C motif) receptor 5 |
ZNF80 | −1,96 | 0,008 | Zinc finger protein 80 |
CADM1 | −1,89 | 0,037 | Cell adhesion molecule 1 |
CD109 | −1,84 | 0,034 | CD109 molecule |
SERPINB6 | −1,80 | 0,003 | Serpin peptidase inhibitor, clade B, member 6 |
PECAM1 | −1,76 | 0,004 | Platelet/endothelial cell adhesion molecule |
NFIA | −1,64 | 0,009 | Nuclear factor I/A |
TIAM2 | −1,64 | 0,008 | T-cell lymphoma invasion and metastasis 2 |
BCL2L14 | −1,63 | 0,032 | BCL2-like 14 (apoptosis facilitator) |
ACPL2 | −1,58 | 0,013 | Acid phosphatase-like 2 |
IFI27 | −1,57 | 0,026 | Interferon, alpha-inducible protein 27 |
CCL17 | −1,54 | 0,019 | Chemokine (C-C motif) ligand 17 |
ALCAM | −1,54 | 0,009 | Activated leukocyte cell adhesion molecule |
H1F0 | −1,50 | 0,020 | H1 histone family, member 0 |
PLA2G4A | −1,49 | 0,030 | Phospholipase A2, group IVA |
HTATIP2 | −1,49 | 0,034 | HIV-1 Tat interactive protein 2, 30 kDa |
SMAD2 | −1,48 | 0,027 | SMAD family member 2 |
ISYNA1 | −1,48 | 0,026 | Inositol-3-phosphate synthase 1 |
ZNF827 | −1,47 | 0,030 | Zinc finger protein 827 |
TAF15 | −1,47 | 0,040 | TBP-associated factor RNA polymerase II |
GATA3 | −1,46 | 0,015 | GATA binding protein 3 |
HLA-DOA | −1,42 | 0,032 | Major histocompatibility complex, class II, DO alpha |
ZNF642 | −1,40 | 0,025 | Zinc finger protein 642 |
GRK5 | −1,39 | 0,041 | G protein-coupled receptor kinase 5 |
ZNF167 | −1,38 | 0,022 | Zinc finger protein 167 |
AARS | −1,37 | 0,021 | Alanyl-tRNA synthetase |
MARS | −1,36 | 0,041 | Methionyl-tRNA synthetase |
ZNF107 | −1,35 | 0,031 | Zinc finger protein 107 |
ZNF443 | −1,35 | 0,022 | Zinc finger protein 443 |