Table 1 Selected genes upregulated in Th1Th17 vs. Th1
Gene symbol | Fold change Th1Th17/Th1 | p-value | Gene title |
|---|---|---|---|
IL17A | 44,94 | 0,000 | Interleukin 17A |
IL22 | 29,18 | 0,000 | Interleukin 22 |
CCL20 | 26,69 | 0,000 | Chemokine (C-C motif) ligand 20 |
IL17F | 10,47 | 0,039 | Interleukin 17 F |
RORC | 7,73 | 0,000 | RAR-related orphan receptor C |
IL26 | 6,90 | 0,000 | Interleukin 26 |
IL23R | 6,14 | 0,000 | Interleukin 23 receptor |
CTSH | 5,46 | 0,000 | Cathepsin H |
CCR6 | 5,38 | 0,001 | Chemokine (C-C motif) receptor 6 |
HPGD | 5,16 | 0,004 | Hydroxyprostaglandin dehydrogenase 15-(NAD) |
PTPN13 | 4,45 | 0,000 | Protein tyrosine phosphatase, non-receptor type 13 |
KLRB1 | 3,87 | 0,040 | Killer cell lectin-like receptor subfamily B, member 1 |
IL1R1 | 3,39 | 0,004 | Interleukin 1 receptor, type I |
CSF2 | 2,68 | 0,041 | Colony stimulating factor 2 (granulocyte-macrophage) |
LST1 | 2,60 | 0,001 | Leukocyte specific transcript 1 |
CXCR6 | 2,44 | 0,003 | Chemokine (C-X-C motif) receptor 6 |
MCAM | 2,27 | 0,001 | Melanoma cell adhesion molecule |
CCR2 | 2,25 | 0,034 | Chemokine (C-C motif) receptor 2 |
RORA | 2,14 | 0,005 | RAR-related orphan receptor A |
CD80 | 2,08 | 0,013 | CD80 molecule |
IL18RAP | 2,05 | 0,049 | Interleukin 18 receptor accessory protein |
PPARG | 2,04 | 0,019 | Peroxisome proliferator-activated receptor gamma |
TNFRSF25 | 2,01 | 0,008 | Tumor necrosis factor receptor superfamily, member 25 |
TNFSF13B | 1,95 | 0,014 | Tumor necrosis factor (ligand) superfamily, member 13b |
LTB | 1,87 | 0,012 | Lymphotoxin beta (TNF superfamily, member 3) |
ARNTL | 1,72 | 0,024 | Aryl hydrocarbon receptor nuclear translocator-like |
IL15 | 1,69 | 0,012 | Interleukin 15 |
FURIN | 1,61 | 0,040 | Furin (paired basic amino acid cleaving enzyme) |
IL12RB1 | 1,56 | 0,031 | Interleukin 12 receptor, beta 1 |
ATF5 | 1,54 | 0,004 | Activating transcription factor 5 |
THY1 | 1,54 | 0,043 | Thy-1 cell surface antigen |
MAP3K4 | 1,53 | 0,003 | Mitogen-activated protein kinase kinase kinase 4 |
CEACAM1 | 1,52 | 0,021 | Carcinoembryonic antigen-related cell adhesion molecule 1 |
MAP3K4 | 1,52 | 0,006 | Mitogen-activated protein kinase kinase kinase 4 |
IL2 | 1,51 | 0,041 | Interleukin 2 |
ATF5 | 1,46 | 0,018 | Activating transcription factor 5 |
CTSC | 1,43 | 0,023 | Cathepsin C |
CD40LG | 1,45 | 0,037 | CD40 ligand |
RUNX1 | 1,40 | 0,012 | Runt-related transcription factor 1 |
PTEN | 1.39 | 0.031 | Phosphatase and tensin homolog |
CD28 | 1,37 | 0,046 | CD28 molecule |
TRIM8 | 1,36 | 0,011 | Tripartite motif-containing 8 |
CASP4 | 1,34 | 0,025 | Caspase 4, apoptosis-related cysteine peptidase |
CYP27B1 | 1,33 | 0,031 | Cytochrome P450, family 27, subfamily B, polypeptide 1 |
FASLG | 1,33 | 0,046 | Fas ligand (TNF superfamily, member 6) |