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Figure 5 | Retrovirology

Figure 5

From: HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling

Figure 5

C/EBPα was overexpressed in ATL. (A) High expression of CEBPA in ATL. CD4 positive cells were isolated from PBMCs of healthy donors and ATL patients, and real-time PCR was performed to analyze the expression of CEBPA mRNA. H indicates healthy donors, P indicates ATL patients. (B) Determination of C/EBPα in ATL patient by immunohistochemical analysis. Lymph nodes of an ATL patient was fixed, and C/EBPα was subjected to immunostaining with anti-C/EBPα antibody. (C) CEBPA is overexpressed in HTLV-1 associated cell lines. Quantitative analysis of CEBPA mRNA in HTLV-1-negative (open bars) and HTLV-1-positive cell lines (black bars) by real-time PCR. (D) Overepression of C/EBPα protein in HTLV-1 cell lines. Celll lystes of HTLV-1-negative and HTLV-1-positive cell lines was subjected to immunoblotting with anti-C/EBPα.

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Retrovirology

ISSN: 1742-4690

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