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Table 1 Potencies of inactivation and breakdown of BaL HIV-1 pseudotyped and replication competent virions by peptide triazoles

From: Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions

Peptide

Viral inactivation

p24 release

gp120 shedding

EC50(nM)

IC50(nM)

IC50(nM)

HNG156

803 ± 120

>500,000

500 ± 230

*5500 ± 1100

* > 200,000

*1800 ± 1000

KR13

23 ± 45

500 ± 80

32 ± 20

*639 ± 71

*4400 ± 930

*1200 ± 930

KR13s

>500,000

>500,000

>500,000

KR13b

52 ± 35

>100,000

120 ± 43

  1. The extents of loss of cell infection, p24 release and gp120 shedding were measured for KR13, KR13b, KR13s and HNG156 treatment of BaL pseudovirus. * Designates the EC50 and IC50 values of the viral infection inhibition, gp120 shedding and p24 release, respectively, obtained for fully infectious HIV-1 BaL virions induced by KR13 and HNG156. All of the IC50 and EC50 values were determined from dose response profiles (Figure 1 and Additional file 1: Figure S12) using Origin Pro.8 (Origin Lab). ± designates the standard deviation of the mean, n > 3.