Peptide | Viral inactivation | p24 release | gp120 shedding |
---|
EC50(nM) | IC50(nM) | IC50(nM) |
---|
HNG156
| 803 ± 120 | >500,000 | 500 ± 230 |
*5500 ± 1100 | * > 200,000 | *1800 ± 1000 |
KR13
| 23 ± 45 | 500 ± 80 | 32 ± 20 |
*639 ± 71 | *4400 ± 930 | *1200 ± 930 |
KR13s
| >500,000 | >500,000 | >500,000 |
KR13b
| 52 ± 35 | >100,000 | 120 ± 43 |
- The extents of loss of cell infection, p24 release and gp120 shedding were measured for KR13, KR13b, KR13s and HNG156 treatment of BaL pseudovirus. * Designates the EC50 and IC50 values of the viral infection inhibition, gp120 shedding and p24 release, respectively, obtained for fully infectious HIV-1 BaL virions induced by KR13 and HNG156. All of the IC50 and EC50 values were determined from dose response profiles (Figure 1 and Additional file 1: Figure S12) using Origin Pro.8 (Origin Lab). ± designates the standard deviation of the mean, n > 3.