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Table 1 Potencies of inactivation and breakdown of BaL HIV-1 pseudotyped and replication competent virions by peptide triazoles

From: Interactions of peptide triazole thiols with Env gp120 induce irreversible breakdown and inactivation of HIV-1 virions

Peptide Viral inactivation p24 release gp120 shedding
EC50(nM) IC50(nM) IC50(nM)
HNG156 803 ± 120 >500,000 500 ± 230
*5500 ± 1100 * > 200,000 *1800 ± 1000
KR13 23 ± 45 500 ± 80 32 ± 20
*639 ± 71 *4400 ± 930 *1200 ± 930
KR13s >500,000 >500,000 >500,000
KR13b 52 ± 35 >100,000 120 ± 43
  1. The extents of loss of cell infection, p24 release and gp120 shedding were measured for KR13, KR13b, KR13s and HNG156 treatment of BaL pseudovirus. * Designates the EC50 and IC50 values of the viral infection inhibition, gp120 shedding and p24 release, respectively, obtained for fully infectious HIV-1 BaL virions induced by KR13 and HNG156. All of the IC50 and EC50 values were determined from dose response profiles (Figure 1 and Additional file 1: Figure S12) using Origin Pro.8 (Origin Lab). ± designates the standard deviation of the mean, n > 3.