Figure 2

Time-dependence of viral breakdown by HNG156 (a) and KR13 (b) treatments of HIV-1 BaL pseudovirus. The % of cell infection retained after peptide treatment is shown on the left y-axes, and the viral protein gp120 and p24 retained in the virus fraction is shown on the right y-axes. All samples were adjusted to the untreated virus as 100% infection and 100% viral protein retention. Each time point had a control of untreated virus, and this was used to normalize each time point of peptide treatment. The concentrations of KR13 and HNG156 were kept constant for each time point at 1 μM and 100 μM, respectively. Untreated controls showed <5% p24 release and gp120 shedding, and <2% loss of cell infection activity. Error bars represent the standard deviation of the mean, n = 3.