Figure 4
From: Relative resistance of HIV-1 founder viruses to control by interferon-alpha
Comparison of the type 1 IFN resistance of virus isolates generated from HIV-infected individuals during acute and chronic, asymptomatic infection. (A) IFNα (left panels) and IFNβ (right panels) Vres (upper half of figure) and IC50 (lower half of figure) values of pairs of virus isolates generated from the same subjects at time-points in acute infection and chronic asymptomatic infection (after 2–7 years of chronic, untreated infection). (B) IFNα (filled circles) and IFNβ (open triangles) Vres values of virus isolates generated from subject MM23 in acute infection and at the indicated time-points during chronic, untreated infection. The data shown in (A) and (B) are the mean of results from a minimum of 2 independent IFNα or IFNβ assays performed with each virus isolate using different donor PBMC mixes.