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Table 5 BI-D anti-retroviral activity EC 50

From: Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

This study

Human cells

Single-round/MT4

Multiple-round/MT4

2.4 ± 0.5 μM

0.17 ± 0.03 μM

Wang et al. study [40]

Mouse cells

LEDGF +/+ WT cells

LEDGF -/- KO cells

2.4 to 2.9 μM

0.16 to 0.20 μM

  1. A comparison of BI-D ARV activity (EC50) assayed in this study (using MT4 human cells) and results reported by Wang et al. (using LEDGF WT and KO mouse cells).