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Figure 6 | Retrovirology

Figure 6

From: Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage

Figure 6

ARV activity in infection assays and effect on the infectivity of virions produced by HeLa-LAV cells. (A) Plot comparing the ARV activity of Mut 101 tested by MR and SR infection assays (using the same concentration scale). (B) Diagram of the experimental setup used to study infectivity of virions produced by HeLa-LAV cells that were treated with Mut101, Raltegravir, SQV, Mut063 or DMSO at the indicated concentrations. (C) Titration of p24 harvested from HeLa-LAV cells treated with the indicated compounds. (D) Infectivity of virions harvested from HeLa-LAV cells treated with the indicated compounds and tested by infection of TZM indicator cells and luciferase assay. (E) Infectivity of virions harvested from Hela-LAV cells treated with the indicated compounds and tested by infection of MT4 cells and cytopathic assay using CellTiter-Glo®.

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