Figure 11
From: Dual-acting stapled peptides target both HIV-1 entry and assembly
The Env mutant V120Q/A327P is replication defective in PBMC. Jurkat T-cell line (a) and PBMCs (b-d) were infected with RT-normalized WT- and V120Q/A327P mutant viruses and cultured in the presence of 30 uM stapled peptides and replication was monitored as described in the Figure 8 legend. The replication of HIV-1 is shown in PBMCs from three different donors (b-d).