Figure 3
From: Decreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo
Maraviroc sensitivity of CD4-independent Envs. Pseudotyped viruses carrying CD4-independent (dotted lines) or control (solid lines) SIV Envs were tested for sensitivity to inhibition by maraviroc. Target cells were 293 T cells transfected with high levels of rmCD4 and rmCCR5 (1 μg each) and treated with various concentrations of maraviroc for 1 hour prior to and during infection.